Ingredient Evidence Review
N-acetylcysteine (600mg)
N-acetyl-L-cysteine (reduced dose)
Last updated 2026-05-19 · 2 primary citations
Mechanism
Your body makes its own primary antioxidant called glutathione. The rate-limiting ingredient is cysteine — NAC is the bioavailable form that gets it where it needs to go. Helps the body clear oxidative damage that accumulates faster under sleep deprivation.
Why we use it
Shift-work biology accumulates oxidative damage faster than a normal sleep schedule. NAC supports recovery. We dose conservatively because acetaminophen co-use is common in this population.
How we dose it
Hericea uses 600 mg per serving (per Post-Shift packet). The clinical trial range that anchors this dose is 600–1,800 mg/day.
600 mg of N-acetylcysteine — half the dose used in our other SKUs. NAC is the precursor to glutathione, the body's master antioxidant. We deliberately lowered the dose for shift workers because they tend to use pain relievers (acetaminophen) more often, and high-dose NAC interacts with that pathway.
Quality & sourcing
USP pharma-grade.
Standard USP NAC.
Cautions
- consult physicianConsult physician if on nitrates or anticoagulants.
Primary literature
Kumar P et al. (2021)
Clin Transl MedPilot trial
Glycine + NAC supplementation restored glutathione levels and improved cognitive measures in older adults.
Foundational human evidence that NAC supplementation reaches the brain antioxidant system at supplement doses.
PMID 33783984
Sekhar RV et al. (2021)
Aging (Albany NY)Mechanism + clinical
Documented that cysteine + glycine availability is the rate-limit on glutathione synthesis in aging adults.
The mechanism paper — explains why we choose NAC specifically rather than supplementing glutathione directly (it doesn't survive digestion).