Ingredient Evidence Review
Omega-3 rTG (microencapsulated)
Re-esterified triglyceride DHA + EPA
Last updated 2026-05-19 · 4 primary citations
Mechanism
DHA is the main building block of your brain's cell walls — roughly 30% of your brain is literally made of DHA. Your body can't make it, you have to eat it. EPA is its anti-inflammatory partner. Together they keep brain cells flexible and reduce the kind of low-grade inflammation perimenopause amplifies.
Why we use it
Most fish oils have far less DHA than EPA. Protect and Perimenopause are both DHA-dominant because the brain story is the priority. Pairs with phosphatidylserine (the previous row) for the cell-membrane rebuilding that the largest recent memory trial in this cohort was built around.
How we dose it
Hericea uses 1,600 mg per serving (per AM stick pack). The clinical trial range that anchors this dose is 900–2,000 mg/day.
1.2 grams of DHA + 400 mg of EPA — far above the typical fish-oil dose. Delivered as a powder mixed into the stick pack (no softgel to swallow) using a microencapsulation technology that keeps the oil from going rancid.
Quality & sourcing
Re-esterified triglyceride (rTG, not ethyl ester); ≥70% TG-form. Croda PowderLoc microencapsulation. TOTOX <10 third-party verified.
Wild-caught small-fish source (sardine/anchovy class); not farmed; not krill.
Cautions
- informationalContains fish (allergen disclosure).
- consult physicianMild antiplatelet effect at gram-level dose; consult physician if on anticoagulants.
Primary literature
Yurko-Mauro K et al. (2010)
Alzheimers DementRCT (MIDAS) · 485 people · 24 weeks · Adults 55+ with memory complaints
MIDAS — 900 mg/day DHA for 24 weeks improved memory and learning in age-related cognitive decline.
The benchmark omega-3-and-memory trial. Set the dose threshold (~900 mg DHA) for cognitive benefit in older adults — we exceed it.
Dyall SC (2015)
Front Aging NeurosciMechanism review
Documents how DHA and EPA support new brain-cell connections, communication, and inflammation control across age.
Explains why omega-3s aren't just 'good for you' — they're structural materials your brain literally cannot make on its own.
Suh SW et al. (2024)
Pharmacol Res PerspectSystematic review
Pooled analysis of omega-3 supplementation trials in elderly adults with Alzheimer's — supports slowing of cognitive decline.
Most recent comprehensive review. Strengthens the case for omega-3 across the cognitive-aging spectrum, where perimenopause sits.
Külzow N et al. (2016)
J Alzheimers DisRCT
Omega-3 supplementation improved memory and increased gray matter volume on brain MRI in older adults.
One of the few trials to show omega-3 actually changes brain structure — not just function — over time.