Ingredient Evidence Review
PQQ (PM dose)
Pyrroloquinoline quinone (reduced form, PM)
Last updated 2026-05-19 · 3 primary citations
Mechanism
Same PQQ as the morning row, taken again in the evening. Mitochondrial growth happens around the clock; cell-energy decline is one of the deepest changes in the 55+ brain. We dose PQQ on both ends of the day to sustain the signal.
Why we use it
Longevity's customer is in the brain decade where cellular-energy decline matters most. The single dose is good; the twice-a-day dose covers a 24-hour window.
How we dose it
Hericea uses 20 mg per serving (per PM packet). The clinical trial range that anchors this dose is 10–40 mg/day.
A second 20 mg PQQ dose at night — keeps the mitochondrial-growth signal going while you sleep. Longevity is the only SKU that doses PQQ twice.
Quality & sourcing
Reduced-form PQQ.
Same supplier as AM PQQ.
Primary literature
Baltic S et al. (2024)
J Nutr Health AgingCombination formulaRCT · 34 people · 6 weeks
A combination of dihydrogen-producing minerals plus PQQ improved cognitive test scores over 6 weeks in elderly adults with memory complaints.
Often cited as PQQ evidence. It tested a combination product, so no effect can be attributed to PQQ on its own.
PMID 38908296
Itoh Y et al. (2016)
Adv Exp Med BiolRCT
PQQ 20 mg/day for 12 weeks was associated with improvements in attention and cognitive measures in healthy middle-aged and elderly adults.
The cleanest single-ingredient PQQ trial at the dose we use.
PMID 26782228
Chowanadisai W et al. (2010)
J Biol ChemMechanism
PQQ stimulated growth of new mitochondria in mammalian cells.
The mechanism — why dosing both AM and PM extends the cellular-energy signal.
PMID 19861415