Ingredient Evidence Review
Reishi fruiting body dual extract
Ganoderma lucidum
Last updated 2026-05-19 · 3 primary citations
Mechanism
Reishi's bitter triterpene compounds help steady the body's stress-hormone (cortisol) response, and its long-chain sugars support immune balance. In the morning that translates to a calmer baseline under sustained pressure — not sedation.
Why we use it
Performance's four-mushroom core. Running Reishi morning and evening gives full-day cortisol and immune coverage, and it's the route the Performance formula takes for its fungal-immune story.
How we dose it
Hericea uses 1,500 mg per serving (per AM stick pack). The clinical trial range that anchors this dose is 1,000–3,000 mg/day.
1.5 grams of the same dual-extracted Reishi as the evening packet, dosed again in the morning. Reishi morning and evening keeps the calming, stress-balancing mushroom working across the whole day.
Quality & sourcing
≥25% beta-glucan; ≥4% ganoderic acids.
Fruiting body dual extract.
Cautions
- consult physicianMild antiplatelet; consult physician if on anticoagulants.
Primary literature
Yao C et al. (2021)
Sci Rep (Nature)Animal model
Reishi extract promoted deeper sleep in mice through a gut-microbiome and serotonin-involved pathway.
Modern mechanism work showing Reishi works through both the gut-brain axis and the brain's serotonin system.
DOI 10.1038/s41598-021-92913-6
Tang W et al. (2005)
Life SciRCT · 132 people · 8 weeks
Standardized Reishi extract reduced fatigue and improved clinician-rated wellbeing more than placebo over 8 weeks in 132 adults with chronic fatigue.
Largest controlled human study of Reishi to date. The fatigue cohort overlaps with the kind of bone-deep tiredness many customers describe.
Wachtel-Galor S et al. (2011)
Herbal Medicine (CRC Press)Comprehensive review
Authoritative academic review of Reishi's chemistry, pharmacology, and clinical use.
Single source if you want the whole evidence base in one place.